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April 3, 1948

CHRONIC BRUCELLOSIS: Conclusions on Treatment After Ten Years

Author Affiliations

Claremont, Calif.

JAMA. 1948;136(14):911-915. doi:10.1001/jama.1948.02890310003002

Only within recent years has chronic brucellosis (undulant fever) been recognized1 as an important cause of many common complaints of a chronic or recurrent nature. The most frequent symptoms2 are fatigability, myalgia, arthralgia, neuralgia, headaches, light-headedness, intractable eye fatigue, sweating, thermolability, myriad digestive dysfunctions, nasal catarrh or chronic sore throat or cough, tachycardia, nervous irritability, depression, insomnia or mental torpor and various disturbances of the reproductive system, especially in the female. The commonest physical findings,1p when there are any, are low grade fever, slightly enlarged liver, increased redness of mucous membranes, tenderness in the right lower quadrant of the abdomen and a suggestive blood picture.1i

The typical history is one of long duration, varied diagnoses, unsuccessful treatment, recurrent course, aggravation of debility following pregnancy, operation or "influenza" and, finally, a conclusion that the patient must be "neurotic" or the complaints "functional" or constitutional. The well known

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