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May 1, 1948


JAMA. 1948;137(1):92. doi:10.1001/jama.1948.02890350094014

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On April 19 the headquarters of the American Medical Association received a wire from Dr. W.F. O'Donnell Jr. of Hazard, Ky., reporting serious reactions in 2 patients immediately following the intravenous use of 5 per cent dextrose in normal saline solution manufactured by Cutter Laboratories, Berkeley, Calif.

The product bore a control number, CM 8164 The American Medical Association immediately notified the Food and Drug Administration of these facts, and a nationwide investigation by federal and state regulatory officials was launched. Not all the facts are yet available, but the following information justifies a warning to all physicians and hospitals.

At least 2 and possibly 4 deaths have occurred in Miami, Fla.; Lexington and Louisville, Ky., following administration of Cutter's dextrose and saline bearing code number CM 8164. At least 8 other serious reactions have been reported, mostly from Southern communities. Several 100 liter bottles with this code number are

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