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March 12, 1955

BACTEREMIA FOLLOWING TONSILLECTOMYEFFECT OF PREOPERATIVE TREATMENT WITH ANTIBIOTICS IN POSTOPERATIVE BACTEREMIA AND IN BACTERIAL CONTENT OF TONSILS

JAMA. 1955;157(11):877-881. doi:10.1001/jama.1955.02950280001001
Abstract

This progress report on a clinical investigation was undertaken to throw light on the questions of: (1) the presence of a transient bacteremia after tonsillectomy that is similar to that observed after tooth extraction and its prevention by preoperative treatment with penicillin and other antibiotics, (2) the amount of information regarding the bacterial content of the deeper lymphoid tissue of the tonsils given by cultures from the surface of the throat, and (3) how antibiotic therapy affects the bacterial content of the deeper structures of the tonsil.

METHOD  Directly after the operation, while the patient was still in the operating room, blood was removed aseptically from the antecubital vein and added to Tryptose Phosphate broth and heart infusion agar for cultures of aerobic and anaerobic bacteria. Adequate penicillinase was added to the culture medium in the cases in which the subjects had been taking penicillin. Half the blood agar plates

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