The effectiveness of choline in removing fat from the liver was first described fifteen years ago by Best and his co-workers.1 Shortly thereafter other substances were found to have similar lipotropic activity, among them being casein,2 an amino acid (methionine)3 and yeast.4 In animal experiments it was demonstrated that choline not only removes fat but also seems to arrest the cirrhotic process.5
Encouraged by results of animal experiments which demonstrated the effect of specific lipotropic substances on the production of cirrhosis on the one hand6 and on the arrest5b and prevention of cirrhosis on the other,7 many clinicians started to apply the physiologic principles learned from these animal experiments to human sufferers of cirrhosis.
This year marked the tenth anniversary of Patek's first paper on the treatment of cirrhosis by a high protein and high vitamin regimen,8 a regimen which signified
STEIGMANN F. EFFICACY OF LIPOTROPIC SUBSTANCES IN TREATMENT OF CIRRHOSIS OF LIVER. JAMA. 1948;137(3):239–243. doi:10.1001/jama.1948.02890370021006
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