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May 22, 1948


Author Affiliations

New York; Prince Frederick, Md.

JAMA. 1948;137(4):363-364. doi:10.1001/jama.1948.82890380002009a

The following report is made at this time because of the favorable effect of adequate dosage of streptomycin and sulfadiazine given concomitantly to a patient suffering from chronic brucellosis due to Brucella suis infection and because there is little in the current literature on the combined use of streptomycin and sulfadiazine in Brucella infection. Also it seems of value, to call attention again to the fact that the hog variety of Brucella (Br. suis) is not confined to the hog-raising regions of the United States.

Sulfadiazine or other sulfonamide compounds have not proved effective in an impressive percentage of cases of chronic brucellosis, although there is much evidence that they may be effective in the acute infection. Even in the acute illness relapse frequently follows discontinuance of the sulfonamide compound.

Streptomycin is not generally accepted as effective against Brucella in vivo, perhaps because of the inconclusive early reports1 of