[Skip to Content]
[Skip to Content Landing]
May 29, 1948

Current Comment

JAMA. 1948;137(5):466. doi:10.1001/jama.1948.02890390044013

VITAMINS OF THE " B " COMPLEX AND RESISTANCE TO MALARIA  The effect of a vitamin deficiency on resistance to infection appears to be dependent on the relative requirements of the infectious agent and of the host for the particular vitamin. If the invading organism requires larger amounts of the vitamin than the host, deficiency of the vitamin appears to increase the resistance to the infection; if, however, the host requires the larger amount of the vitamin, deficiency decreases the host's resistance. Increased resistance to malarial infection is found in deficiencies of both riboflavin and pantothenic acid in chickens and in lack of ascorbic acid in monkeys. Deficiencies may be produced not only by low levels of the vitamins in the diets but also by the administration of analogous compounds which antagonize the vitamins; one of these compounds, pantoyltauramido-4-chlorobenzene, has been found to be four times as effective as quinine in the