Anemia is a frequent associate of cancer. Gross1 of the Veterans Administration Hospital, New York, has observed a direct destruction of erythrocytes by species-specific hemolysins formed or liberated by the cancer cells. Tumor extracts were made from 10 different spontaneous mammary cancers from female mice of a cancer strain and from 2 different transplanted tumors originated as mammary cancers in such females and carried through successive transplantations. Cell suspensions varying from 15 to 30 per cent were made by grinding tumor tissue in sodium chloride solution; the suspensions thus obtained were either repeatedly centrifuged or passed through a filter to form a clear sterile aqueous extract. One cubic centimeter of a 1 per cent washed suspension of red blood cells from the same strain of mice was mixed with 0.5 cc. of this extract, and the resulting mixture incubated at 37 C. for 2 1/2 to 3 hours. The
CANCER HEMOLYSINS. JAMA. 1948;137(7):647. doi:10.1001/jama.1948.02890410069009
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