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April 9, 1955


JAMA. 1955;157(15):1300-1302. doi:10.1001/jama.1955.02950320030008a

The steroid hormones have influenced modern therapeutic methods during the past five years to a greater extent than any other modality, with the possible exception of the broad spectrum antibiotics. Corticotropin (ACTH), cortisone, and hydrocortisone have found some use in almost every branch of medicine. Corticotropin and cortisone were found to be ineffective when applied locally to the skin but, when administered systemically, play a considerable role in the control of allergic and nonallergic inflammatory dermatoses. Hydrocortisone, applied locally in the form of lotions or ointments in concentrations as low as 0.5%, produces a beneficial response in many dermatological conditions. Fried and Sabo, while attempting to synthesize hydrocortisone from 11-epi-17α-hydroxycorticosterone, found that the 9α-halo derivatives of 17α-hydroxycorticosterone, which were intermediate products of the synthesis, were highly active in the rat liver glycogen assay for 11-oxygenated corticoids. They further noted that the activity was inversely proportional to the size of the