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June 19, 1948


JAMA. 1948;137(8):702-703. doi:10.1001/jama.1948.02890420036010

The parental administration of nutrients has proved of vital importance in medicine. Lextrose, salt and water given intravenously have long been a dependable device for providing fluid, electrolyte and energy; to this mixture more recently proteins or protein derivatives such as casein digests or mixtures of amino acids have been added, thus amplifying the adequency of the nutrition. In peritoneal lavage, solutions resembling the electrolyte pattern of blood are injected into the body cavity. Preparations of its fat-soluble vitamins are available for intramuscular injection, though their utilization by this route is less complete than when given orally. Currently, one of the drawbacks of intravenous alimentation is the inability to supply the required calories; the addition of fat to the infusion mixture would tend to remedy this deficiency.

Studies have been reported recently indicating the satisfactory use of fat for intravenous alimentation in experimental animals. Refined coconut oil emulsions stabilized with