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This excellent monograph will aid any student of hyperinsulinism. The author has been interested in hyperinsulinism for fifteen years. The volume of two hundred and fifty six pages contains twentyfive figures, 5 colored plates and seven chapters with a bibliography so extensive that it exceeds expectation. The literature is carefully reviewed, and the author's own investigations are presented without dogmatism.
In chapter 1 an excellent review is given of the experimental etiology of diabetes. The hypersecretion of the two minor hormones, vagotonin and lipocaic, as well as of the major hormone, insulin, may be accompanied by the hyposecretion of one of the other hormones. Rightly the author discerns the lack of close correlation between hyperplasia of islet cell tissue and overproduction of insulin, making the diagnosis of hyperinsulinism difficult from the histologic appearance of the pancreas. Incidentally, the five types of cells found in the pancreas, varying principally according to
L'hyperinsulinie: Les états de suractivité fonctionnelle du pancreas endocrine en médecine expérimentale et en clinique. JAMA. 1948;137(9):819–820. doi:10.1001/jama.1948.02890430061026