The antianemic properties of folic acid have been demonstrated repeatedly,1 and this work has been summarized by Berry and Spies.2 It has also been emphasized that folic acid is effective in those patients with macrocytic anemia who also exhibit megaloblastic erythropoiesis in the bone marrow.3 It is still not known, however, whether folic acid therapy is able to produce and maintain in patients with addisonian pernicious anemia complete hematologic and clinical remission, nor are the optimum dosage of folic acid and the preferable method of administration definitely established.
In the course of an investigation of the therapeutic role of folic acid, the details of which will be reported at a later date, 2 patients with addisonian pernicious anemia were encountered whose clinical course while they were receiving folic acid was characterized by a symptomatic relapse. The histories of these patients are reported now because of their clinical
JACOBSON SD, BERMAN L, AXELROD AR, HEIDE ECV. FOLIC ACID THERAPY: Its Effect as Observed in Two Patients with Pernicious Anemia and Neurologic Symptoms. JAMA. 1948;137(10):825–827. doi:10.1001/jama.1948.02890440001001
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