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July 10, 1948

Histopathologic Technic

JAMA. 1948;137(11):998. doi:10.1001/jama.1948.02890450078025

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Manuals of histologic technic often resemble old pharmacopeias or cook books in that they are compendiums of huge numbers of empiric recipes often differing by only minute quantities of one or several ingredients. The vast majority of the recipes are rarely tried, and many formulas have been retained out of inertia, piety or ignorance of the role of the ingredients. The present manual represents a partial break with this tradition. It is an attempt to remove some of the uncertain elements of the art of staining and to make of it a more exact craft by the use of buffered solutions and accurately delineated dyes. Some improvement is also attained in this manual by tabular arrangement of variant procedures which clarifies the differences. The table on page 22 for the conversion of prices of solvents in avoirdupois units to current prices per liter seems superfluous.

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