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July 10, 1948

Tratamiento dd las leucemias con alkilaminas

JAMA. 1948;137(11):999-1000. doi:10.1001/jama.1948.02890450079033

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This clinical monograph reports the experiences of the author in the use of nitrogen mustard therapy. Thirteen cases of various leukemias and a seminoma are presented. In 7 cases correlation is developed between the clinical, hematologic and pathologic changes following the use of this drug. The methods of therapy and the toxic manifestations observed are in accord with earlier reports on this subject. Clinical improvements reported are a reduction in the splenomegaly, hepatomegaly, adenopathy and a general well-being of the patients.

The author describes the hematologic changds in leukemia which developed during therapy as (1) a process of maturation of the leukocytes which is followed by a quantitative reduction, (2) a period of leukopenia followed by spontaneous rise to normal value, (3) a development of normal hemogram and myelogram and (4) complete regeneration of the hemopoietic system. The author believes that the methyl bis beta-chloroethylamine hydrochloride has a selective action

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