After the introduction of penicillin as an effective agent in the treatment of early syphilis1 other therapeutic measures were given in combination with it to determine whether the effectiveness could be increased by these procedures It was shown experimentally that there was a therapeutic synergism between penicillin and oxophenarsine hydrochloride2 in vitro, as well as between penicillin and fever therapy.3 A preliminary report4 had indicated that the use of penicillin and physically induced fever might be worthy of study in man
There are two mam problems in the study of such a combination. First, will the addition of fever result in an appreciable increase of favorable results over the therapeutic effectiveness of the same amount and kind of penicillin administered for the same period without fever? Secondly, can the duration of treatment with penicillin be shortened without the loss of efficiency by the addition of fever?
SCHWEMLEIN GX, BAUER TJ, CRAIG RM, RODRIQUEZ J, BUNDESEN HN. PENICILLIN AND FEVER THERAPY IN EARLY SYPHILIS. JAMA. 1948;137(14):1209–1212. doi:10.1001/jama.1948.02890480029007
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