Clinical interest in the anesthetic activity of the antihistamines has been greatly stimulated by the need to provide safe and effective anesthesia for patients who have shown atopic responses to commonly used topical anesthetic preparations. About two years ago we presented a preliminary report on the use of tripelennamine (Pyribenzamine) hydrochloride for the production of topical urethral anesthesia; this report reviewed the pertinent literature. In the preliminary report the results obtained with tripelennamine hydrochloride solution in our first 100 patients were presented. A 4% solution had been used in the first 50 on a purely empirical basis, and, because of the fairly high incidence of initial burning on instillation into the anterior urethra (18 of the 50 complained of a degree of burning rated 2 to 4+), a 2% solution of the drug was used in the next 50 patients, with a gratifying reduction in that complaint. In all cases,
Fitzpatrick RJ, Orr LM. TRIPELENNAMINE HYDROCHLORIDE FOR TOPICAL URETHRAL ANESTHESIA. JAMA. 1955;158(4):261. doi:10.1001/jama.1955.02960040019006
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