Bone marrow was obtained in living patients for the first time in 1903 independently by Pianese1 and Wolff.2 These authors punctured the femur and the tibia respectively in search of another diagnostic aid in detecting parasitic infestation. At first this method of bone marrow study didnot gain much recognition, since these sites of puncture in adults normally contain little active marrow and therefore failed to prove of diagnostic value in hematologic investigation.
It was only twenty years later that interest in bone marrow studies in vivo was reawakened when Seyfarth3 in 1923 trephined the sternum and ribs in order to obtain hemopoietically active bone marrow. It remained for Arinkin4 further to simplify the procedure by introducing in 1928 the technic of aspiration of the sternum, rendering examination of bone marrow a readily available and routine hematologic procedure. The sternum became the site of election for obtaining
RUBINSTEIN MA. ASPIRATION OF BONE MARROW FROM THE ILIAC CREST: Comparison of Iliac Crest and Sternal Bone Marrow Studies. JAMA. 1948;137(15):1281–1285. doi:10.1001/jama.1948.02890490009003
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: