During the past few years several reports have appeared that indicate that injectable antihistaminic drugs are useful for the prevention of allergic and pyrogenic blood transfusion reactions. Ferris, Alpert, and Coakley1 reported on their experience with 607 transfusions following the addition of 25 mg. of tripelennamine (Pyribenzamine) to 500 ml. of whole blood. Compared with a control group the incidence of allergic reactions was reduced from 2.69 to 0.16%. Surprising, however, was their observation that by the same method the incidence of pyrogenic reactions was reduced from 4.31% to none. The authors concluded, by citing the lack of adequate understanding of the pathophysiology of pyrogenic reactions, that pyrogenic reactions may be a response to histamine liberation and may occur on an allergic basis. More recently Frankel and Weidner2 suggested the use of chlorprophenpyridamine (Chlor-Trimeton) maleate for the prevention of allergic and pyrogenic reactions and stated that they had
Wilhelm RE, Nutting HM, Devlin HB, Jennings ER, Brines OA. ANTIHISTAMINICS FOR ALLERGIC AND PYROGENIC TRANSFUSION REACTIONS. JAMA. 1955;158(7):529–531. doi:10.1001/jama.1955.02960070005002
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