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August 28, 1948


Author Affiliations

Toronto, Canada

JAMA. 1948;137(18):1596-1599. doi:10.1001/jama.1948.82890520015010

It is impressed on every physician occasionally and on some ill fated patients at short intervals that renal function is a vital one. The sudden onset of acute anuria following blood transfusion, the acute toxemias of pregnancy and otherwise, following certain poisonings or the administration of sulfonamide drugs, etc., sets off an alert in the attending physician. With reasonable luck, many of these patients will recover function within a few hours or days, when the "stand easy" signal arrives, with great relief to the physician. However, if such fortuitous circumstances do not establish themselves, after the fifth or sixth day of anuria the physician is faced with an ominous set of circumstances over which he has little control. There are the average and orthodox methods of treatment, but, by and large, these have relatively little effect in changing the course of events which are indicated by the acute anuria. At