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September 4, 1948

PREVENTION OF POSTOPERATIVE PULMONARY INFECTIONS: Inhalation of Micropowdered Penicillin and Streptomycin

Author Affiliations

Los Angeles; Rochester, N. Y.; Rochester, N. Y.

JAMA. 1948;138(1):4-8. doi:10.1001/jama.1948.02900010006002

The prevention of pulmonary complications following major abdominal or thoracic surgical intervention is still a matter of deep concern, especially in the northeastern sections of the United States where chronic sinusitis and chronic basilar pulmonary infection are rather common. Pulmonary complications are of two general groups, those associated with pulmonary emboli and those associated with bacterial infection with or without atelectasis. Only the second type is to be considered in this report. The use of chemotherapeutic agents, particularly penicillin and, more recently, streptomycin, has been valuable in reducing the incidence of these complications, but the methods of administration, dosage and ideal duration of treatment are still a matter for some debate.1 In the series of patients to be presented, stress has been placed on an accurate knowledge of the preoperative bacterial flora of the upper part of the respiratory tract and an attempt has been made to reduce the