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June 25, 1955


JAMA. 1955;158(8):689. doi:10.1001/jama.1955.02960080065020

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To the Editor:—  The recent letter to the Editor from Dr. J. S. Shuman detailing the production of signs of paralysis agitans by reserpine therapy in a patient with severe psychoneurosis (J. A. M. A.158:73 [May 7] 1955) warrants calling attention to earlier reports on the same subject. At the annual meeting of the Spanish Neurological Society in Madrid in 1953, Dr. Magendra Nath reported on Parkinsonism produced by Rauwolfia serpentina. Dr. E. Weber of the department of psychiatry of the University of Zurich described the development of signs of paralysis agitans in psychotic patients treated with reserpine (Schweiz. med. Wschr. 84:968, 1954). Drs. N. S. Kline and A. M. Stanley (Ann. New York Acad. Sc.61:85, 1955) and Dr. V. Kinross-Wright (Ann. New York Acad. Sc.61:174, 1955) also have reported on paralysis agitans as a toxic or side-effect during reserpine treatment of psychotic

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