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Article
September 11, 1948

AUREOMYCIN: Experimental and Clinical Investigations

Author Affiliations

Baltimore

From the Department of Preventive Medicine, Johns Hopkins University School of Medicine, Baltimore.

JAMA. 1948;138(2):117-119. doi:10.1001/jama.1948.02900020013004
Abstract

Aureomycin is an antibiotic derived from a strain of Streptomyces aureofaciens. It is supplied as a yellow crystalline hydrochloride salt which is soluble in distilled water but somewhat less soluble in isotonic sodium chloride solutions. These solutions are acid (pH 4.5). The activity of the antibiotic deteriorates rapidly in alkaline solution at room temperature.

IN VITRO STUDIES  Aureomycin has been shown to possess antibacterial activity against numerous gram-positive and gram-negative bacteria. Beta hemolytic streptococcic strains, groups A. D, F and G, and three strains of Streptococcus faecalis were susceptible to the effects of 0.3 to 1.25 micrograms of aureomycin per milliliter; Diplococcus pneumoniae types I, II and III were susceptible to 0.1 to 0.3 microgram, staphylococci to 0.6 microgram per milliliter, strains of Bacillus coli aerogenes to 5.0 micrograms per milliliter; Klebsiella pneumoniae to 1.0 to 5.0 micrograms per milliliter, Hemophilus influenzae to 2.0 micrograms per milliliter, and Brucella

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