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September 11, 1948


Author Affiliations

Poughkeepsie, N. Y.

JAMA. 1948;138(2):127-128. doi:10.1001/jama.1948.62900020002007a

The basis for this report is a fatality subsequent to the intravenous administration of iodopyracet injection ("diodrast"). The incidence of such fatalities is rare. Pendergrass and his co-workers,1 in 1942, following a fatal reaction to iodopyracet injection at the University of Pennsylvania, made a survey of this diagnostic procedure throughout the United States and Canada. They sent out three thousand questionnaires to radiologists and urologists and received a report on 661,800 urographic examinations. In analyzing these reports, they encountered twenty-six unreported fatal reactions to iodopyracet injection in addition to eleven fatalities that had been reported in the literature up to that time. This represented an incidence of one fatality to twenty-five thousand injections. They reported two types of deaths: (1) immediate, due to allergy to the drug, and (2) delayed, due to preexisting major renal damage. Eleven of twenty-six deaths were immediate deaths, occurring in an average time of