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October 9, 1948

AUREOMYCIN: A NEW ANTIBIOTIC WITH VIRUCIDAL PROPERTIES: I. A Preliminary Report on Successful Treatment in Twenty-Five Cases of Lymphogranuloma Venereum

Author Affiliations

New York

From the Surgical Department of Harlem Hospital, Department of Hospitals, New York, and the Ophthalmological Department, College of Physicians and Surgeons, Columbia University, New York.

JAMA. 1948;138(6):408-412. doi:10.1001/jama.1948.02900060012006

As a result of a comprehensive screening program at the Lederle Laboratories Division, American Cyanamid Company, a substance has been obtained from a Streptomyces which gave promise of possessing unusual antibiotic properties. The antibiotic has been named aureomycin, and a statement regarding its specific properties and chemical purification will be published elsewhere.1 Of special interest to us was the striking spectrum of activity exhibited by this antibiotic against many rickettsiae and certain viruses.2 In particular, it was noted that aureomycin was highly effective in the treatment of mice infected intracerebrally with the virus of lymphogranuloma venereum.

In view of the information made available to us concerning the unusual therapeutic range of aureomycin, it seemed desirable to use this antibiotic in human beings suffering from lymphogranuloma venereum. An added incentive to the study was the realization that effective treatment has not been available for this disease. Although claims have