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August 13, 1955


JAMA. 1955;158(15):1344-1347. doi:10.1001/jama.1955.02960150014003

In recent years agammaglobulinemia, more properly called reduced gammaglobulinemia or hypogammaglobulinemia, has been reported in children.1 This recently described entity is characterized by recurrent, severe bacterial infections, which are evidence of deficient antibody production associated with almost complete absence of serum gamma globulin but with relatively normal total protein concentration. A patient with an abnormally low serum gamma globulin level, while under our care, developed a severe surgical wound infection. We believe this patient's hypogammaglobulinemia either was responsible for, or contributed to, her severe wound infection. To our knowledge no such condition has been reported as occurring in an adult; however, during the preparation of this paper, Sanford and his co-workers2 reported on an adult female, 39 years of age, who had a low serum gamma globulin level accompanied by bronchiectasis and a sprue-like syndrome. Their patient improved markedly after administration of gamma globulin at monthly intervals. Subjective