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October 23, 1948

Current Comment

JAMA. 1948;138(8):596. doi:10.1001/jama.1948.02900080054012

HEPATIC LOCALIZATION OF EMETINE HYDROCHLORIDE  While emetine hydrochloride is efficient in the treatment of amebic hepatitis, it is less reliable in the treatment of amebic dysentery. Despite its ability to clear up the acute symptoms, relapses frequently occur. A logical explanation of this failure is offered by Palmer,1 of the Army Medical Center, Washington, D. C., from his study of the topographic distribution of emetine in laboratory animals. Twenty-four albino rabbits each received intramuscularly injections with 6 mg. per kilogram of body weight of emetine hydrochloride. At various intervals after the injection emetine assays were made of the liver and intestinal walls. At the end of one hour 24.9 mg. per kilogram were found in the liver. At this time there was only a concentration of 5.5 mg. per kilogram in the large intestinal walls. The concentration in the liver increased to a maximum of 41.6 mg. per kilogram

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