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October 23, 1948


Author Affiliations

Professor of Pathology. University of Chicago.

JAMA. 1948;138(8):609. doi:10.1001/jama.1948.02900080067021

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To the Editor:—  A recent article in The Journal gives voice to a statement which is occasionally made, sometimes accepted and too often practiced; yet it should not go unchallenged lest it be assumed by others that the idea is approved by a wide circle of the author's pathologist colleagues. This letter is not a challenge to the author's main thesis on the value of heterologous tissue transplants (Greene, H. S. N.: Identification of Malignant Tissues, J. A. M. A. 137:1364-1365 [Aug. 14] 1948), but only to an introductory statement to the effect that the characterization of tissues as malignant or cancerous is based solely on morphologic considerations in most laboratories. The idea is a half truth as it stands. The diagnosis is not usually solely so based, but rather on morphologic considerations interpreted in the light of subsequent course in a large past experience with similar tumors. Such

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