Prior to the use of chemotherapeutic agents, subacute bacterial endocarditis was rarely if ever cured. With the increasing use of sulfonamide compounds in the treatment of this condition, series of cases were reported in which apparent cures were achieved in approximately 5 per cent of patients treated.1 Recent experience with penicillin in a number of well substantiated series2 indicates that the percentage of patients cured is substantially higher than among patients treated with sulfonamide compounds. It is the purpose of this communication to show the results of penicillin therapy in 18 consecutive cases of subacute bacterial endocarditis.
Selection of Cases.—
In the two year period from Jan. 1, 1944 to Dec. 31, 1945, 18 patients with subacute bacterial endocarditis were admitted to St. Luke's Hospital. The diagnosis was established in each instance by the clinical history, physical findings and repeated positive blood cultures.Table 1 shows
HERRING AC, DAVIS WM. PENICILLIN TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS: Report of Eighteen Consecutive Cases. JAMA. 1948;138(10):726–730. doi:10.1001/jama.1948.02900100006002
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: