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Article
November 6, 1948

PENICILLIN TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS: Report of Eighteen Consecutive Cases

Author Affiliations

New York

From the Medical Service, St. Luke's Hospital.

JAMA. 1948;138(10):726-730. doi:10.1001/jama.1948.02900100006002
Abstract

Prior to the use of chemotherapeutic agents, subacute bacterial endocarditis was rarely if ever cured. With the increasing use of sulfonamide compounds in the treatment of this condition, series of cases were reported in which apparent cures were achieved in approximately 5 per cent of patients treated.1 Recent experience with penicillin in a number of well substantiated series2 indicates that the percentage of patients cured is substantially higher than among patients treated with sulfonamide compounds. It is the purpose of this communication to show the results of penicillin therapy in 18 consecutive cases of subacute bacterial endocarditis.

CLINICAL DATA 

Selection of Cases.—  In the two year period from Jan. 1, 1944 to Dec. 31, 1945, 18 patients with subacute bacterial endocarditis were admitted to St. Luke's Hospital. The diagnosis was established in each instance by the clinical history, physical findings and repeated positive blood cultures.Table 1 shows

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