In acquiring more precise pharmacologic knowledge about chemicals used in medicine, the alert physician is able more satisfactorily to apply such information for the benefit of his patients, whether in the diagnosis, prevention or treatment of disease. In spite of the great numbers of useful new drugs being introduced into medicine for various purposes, the most important development of current pharmacology is theoretical, in connection with the establishment of general principles. An acquaintance with general principles of pharmacology, especially as developed by Clark,1 is being recognized as increasingly helpful in the practical clinical use of drugs.
It may seem peculiar to the hard-headed clinician not to offer any specific information in this discussion about any particular drug. He may ask what value it is to him in trying to help his patients to have some general ideas about time-concentration relationships, since what he wants to know is how much
LEAKE CD. CURRENT PHARMACOLOGY: General Principles in Practical Clinical Application. JAMA. 1948;138(10):730–737. doi:10.1001/jama.1948.02900100010003
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