The purpose of this paper is to emphasize the danger of bone marrow depression inherent in the use of nitrogen mustard (Mustargen) and triethylene melamine (TEM). The treatment of the malignant lymphomas with these drugs has been described by many investigators since the reports of Gilman1 in 1945 and Karnofsky2 in 1951. These compounds have been used mainly in the treatment of diffuse or generalized forms of the disease. Most investigators feel they are a welcome addition to the therapeutic armamentarium. The danger of total bone marrow depression has been noted before. In 20 courses of nitrogen mustard, Taffel3 encountered 5 cases of severe leukopenia and 8 of moderate leukopenia. Thrombocytopenia occurred in six patients, four of whom developed spontaneous hemorrhages. Two deaths due to toxicity were observed by Kurnick and associates4 while treating 24 cases of Hodgkin's disease. Six other patients developed marrow depression. They
Mrazek RG, Wachowski TJ. HEMATOPOIETIC DEPRESSION FROM NITROGEN MUSTARD AND TRIETHYLENE MELAMINE. JAMA. 1955;159(3):160–163. doi:10.1001/jama.1955.02960200006002
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