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Article
November 20, 1948

LYMPHOCYTES AND GLOBULIN

JAMA. 1948;138(12):890-891. doi:10.1001/jama.1948.02900120032010
Abstract

At a recent conference on lymph held by the New York Academy of Sciences, White and Dougherty1 presented important statements on the newer knowledge of lymphocytes. The Yale investigators said that the structure and function of lymphoid tissue are controlled by pituitary-adrenal cortical secretion and that changes can be observed in this tissue following stimulation of the pituitary or the administration of adrenal cortical preparations. The changes are: a dissolution of lymphocytes in lymphoid structures, a profound lymphopenia, an increase in serum beta globulins and gamma globulin and, in the immunized animal, a release of antibody globulin to the circulation.

The dissolution of lymphocytes is characterized by a shedding or budding of the lymphocyte cytoplasm. As a consequence, this material is released to the lymph and, thus, to the systemic circulation. Lymphocytes, in the normal animal, contain a protein identical with the normal serum gamma globulin; a second component

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