A better understanding of the role of the sympathetic nervous system, antisympathetic drugs, antibiotics and refrigeration has converted the emergency amputation to an elective procedure. The surgeon, confronted with a gangrenous extremity, now has several aids that he may use to save the patient's life and to conserve tissue formerly sacrificed. Increasing interest in the conservative management of certain sequelae of vascular disease is evidenced by such recent reports as those of Wirtschafter and Widmann.1 This report contains our experience with the use of histidine and ascorbic acid in the conservative treatment of one type of peripheral vascular disease as first suggested by Wirtschafter and Widmann.
Holtz2 advanced the theory that histamine was formed in vitro and in vivo by the action of ascorbic acid with histidine. Block and Pinösch3 found that there was an increase of histamine in the lungs of guinea pigs following administration of
FRIEDELL MT, DRUCKER EF, PICKETT WJ. HISTIDINE AND ASCORBIC ACID TREATMENT OF ARTERIOSCLEROSIS OBLITERANS: With Radioactive Isotope Estimations of Circulatory Effects. JAMA. 1948;138(14):1036–1039. doi:10.1001/jama.1948.02900140028006
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