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December 11, 1948

d-TUBOCURARINE IN WAX AND OIL: For Control of Muscle Spasm in Tetanus

Author Affiliations


From the Department of Medicine, Wayne University College of Medicine and The Detroit Receiving Hospital.

JAMA. 1948;138(15):1087-1090. doi:10.1001/jama.1948.02900150017005

In the treatment of tetanus, the primary aims are neutralization of the toxin and control of tetanic muscle spasms. Whereas a therapeutically sound regimen for administration of antitoxin has been formulated,1 control of the convulsions and muscle spasm has remained unsatisfactory. The purpose of this paper is to report the effect of a new preparation, d-tubocurarine in wax and oil,2 on the convulsions and muscle spasm in this disease. Each cubic centimeter of this preparation contains 175 mg. of d-tubocurarine in 4.8 per cent wax in peanut oil. Our results with this material in 3 consecutive patients with tetanus who lived have been sufficiently good to warrant more extended observation.


Case 1.—  R. Z. (fig. 1), an 11 year old white school boy, was admitted to the Detroit Receiving Hospital June 11, 1947, complaining of frontal headache and cramping pains in the left leg and