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October 15, 1955


JAMA. 1955;159(7):708. doi:10.1001/jama.1955.02960240074020

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To the Editor:—  We wish to take issue with some of the conclusions in the articles concerning the effects of cobalt on thyroid function that appeared in The Journal of Aug. 13, 1955, pages 1347 to 1357. In addition, we wish to describe further experiences since our observations (J. A. M. A.157:117-121 [Jan. 8] 1955) that led us to conclude that cobalt is a goitrogen in man. Our reasons for so concluding are worthy of emphasis. 1. Hyperplastic goiters and hypothyroidism were observed to develop during administration of cobalt. 2. Tests of thyroid function showed evidence of marked suppression of normal activity during drug therapy. 3. Clinical and laboratory recovery occurred after withdrawal of cobalt.Holly (on page 1349 of the Aug. 13 issue) purports to present "complete investigations in animals and pregnant women." Of the group of 78 pregnant women, 58 patients are apparently the same group

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