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December 18, 1948

Tuberculin Allergy

JAMA. 1948;138(16):1184. doi:10.1001/jama.1948.02900160052016

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In an editorial by this title in The Journal, Nov. 13, 1948, page 823, reference was made to research by several investigators including that of A. B. Stavitsky which, the latter states, is misinterpreted. Dr. Stavitsky writes that he never has transferred tuberculin hypersensitivity from tuberculous guinea pigs by a massive transfer of whole blood. These animals, he writes, were given injections of heat-killed tubercle bacilli and were tuberculin sensitive but not tuberculous. Dr. Stavitsky states also that he never expressed the opinion that circulating lymphocytes in this whole blood were responsible for this transfer. What he said was as follows: "The positive results employing suspensions containing about 95 per cent lymphocytes are indicative of the possible preeminence of this cell in the transfer of sensitivity. The specific lysis of a portion of small mature lymphocytes from blood or spleen of tuberculous mice and guinea pigs upon contact with tuberculin

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