Aureomycin is an antibiotic derived from a strain of Streptomyces aureofaciens).1 It has been found to protect mice and guinea pigs infected with the rickettsia of Q fever, Rocky Mountain spotted fever, murine typhus and rickettsial pox.2 The drug is readily absorbed after oral administration. Although quantitative assay in the body fluids has not been satisfactory, low levels (0.3 to 2.5 micrograms per millimeter) have been detected in the blood serum and levels up to 320 micrograms per milliliter3 in the urine. Pharmacologic studies in animals have shown that the toxicity of the drug is low except after intravenous administration where hemoglobinuria and anemia have been noted.4 In human beings, therapeutic doses up to 60.0 milligrams per kilogram of body weight per day given orally have not been associated with any toxic manifestations except for occasional nausea and vomiting.5 The latter has been transient and
ROSS S, SCHOENBACH EB, BURKE FG, BRYER MS, RICE EC, WASHINGTON JA. AUREOMYCIN THERAPY OF ROCKY MOUNTAIN SPOTTED FEVER. JAMA. 1948;138(17):1213–1216. doi:10.1001/jama.1948.02900170007002
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