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October 22, 1955


JAMA. 1955;159(8):807. doi:10.1001/jama.1955.02960250069021

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To the Editor:—  The purpose of this communication is to point out the effectiveness of amphetamine for the relief of overactivity, restlessness, and involuntary movement in ordinary (Sydenham's) chorea. Review of a number of articles on chorea reveals that this drug, which I have found helpful, has not received recognition for its usefulness in this connection. My attention was first drawn to the possibilities of amphetamine in ordinary chorea by my experience with the following case.The patient was a 16-year-old girl with a chief complaint of uncontrollable movements. These had become increasingly more severe over a period of one month. During this period, the patient had also become increasingly more irritable. She was overemotional, overactive, unreasonable, and so difficult to manage that she was considered to be psychotic and admitted first to a psychiatric unit. The medical history included frequent attacks of tonsillitis, with three recurrences during the month

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