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December 25, 1948


Author Affiliations

Baltimore, Md.

JAMA. 1948;138(17):1253. doi:10.1001/jama.1948.02900170047019

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To the Editor:—  I read with interest the editorial in The Journal, October 2, page 367, on the subject of "Salicylate Therapy in Rheumatic Fever." In this connection, you quote Coburn's work (Coburn, A. F.: Salicylate Therapy in Rheumatic Fever, Bull. Johns Hopkins Hosp., Dec. 1943, pp. 435464). If verified, such results would indicate a good method of treating rheumatic fever. However, an analysis of his results casts reasonable doubt on the validity of the conclusions. It is because this subject is such a vital one, and not in order to detract from the value of the work published, that the following considerations are brought forward.In presenting the results, the criteria for determining cardiac damage are not described. The follow-up period seems to be too short to determine adequately the ultimate effect of the acute rheumatic episode or of the treatment, for pathologically demonstrable valvular heart disease may

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