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December 25, 1948


Author Affiliations

Aberdeen, N. C.

JAMA. 1948;138(17):1253. doi:10.1001/jama.1948.02900170047020

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To the Editor:—  Recent contributors to The Journal found hexachlorocyclohexane to be an effective and safe treatment for scabies even when spread on and rubbed into the entire cutaneous surface of the body in a vanishing cream base (Canon and McRae, The Journal, Oct. 23, pp. 557-560). Before this mode of treatment is accepted it seems that consideration should be given to the fact that recent experiments not cited by these authors show that both oily (Horton, Karel and Chadwick, Science, March 5, pp. 246-247) and aqueous (personal communication from Dr. Garner, U. S. Department of Agriculture Animal Research Department, Beltsville, Md., on work done by Department of Agriculture research workers at Kerrville, Texas) solutions of hexachlorocyclohexane can be fatal to rabbits and other animals by cutaneous absorption alone.In addition to the possibility that hexachlorocyclohexane may be toxic on cutaneous absorption consideration should be given to its possible toxic

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