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October 29, 1955


JAMA. 1955;159(9):848-850. doi:10.1001/jama.1955.02960260018006

GOITER IN NEWBORN INFANT DUE TO MOTHER'S INGESTION OF PROPYLTHIOURACIL  Harold H. Aaron, M.D. Samuel J. Schneierson, M.D. and Edward Siegel, B.S., New YorkIt is customary to classify congenital goiter into two groups: that occurring in endemic goiter regions and that occurring in nongoitrous areas in which there is no iodine lack.1 In this presentation we are concerned with an instance of marked thyroid enlargement in a newborn infant in a nonendemic area. The etiology became clear when it was ascertained after birth that the mother had been continuously on a regimen of propylthiouracil for a period of 10 months preceding delivery.

REPORT OF A CASE  An infant, weighing 7 lb., 14 oz. (3,572 gm.) at birth, was delivered spontaneously, without obstetric difficulty, at Lebanon Hospital on Feb. 9, 1954. At once it was evident that the infant was in moderate respiratory distress, that there was marked enlargement