Only a few cases of insulin shock therapy during pregnancy are reported in the literature. Goldstein, Weinberg, and Sankstone reported the employment of insulin subcoma therapy on 13 treatment days, following a course of pentylenetetrazol (Metrazol) convulsive therapy, without harm to the child. Although their description does not mention just when in the course of the pregnancy insulin was used, one infers that it was after the gestation was at least four months advanced. McConnell in 1945 mentioned two cases: insulin coma therapy was started when one of the patients was 10 weeks' pregnant and the other 14 weeks' pregnant. Neither showed any abnormal symptoms during treatment, and both delivered normal babies. One of these children was 9 months old and the other was over one year old at the time the paper was written. On the other hand, Gralnick had less fortunate experience with two patients treated by means
Luhan JA, Tuteur W. INSULIN COMA THERAPY IN ADVANCED PREGNANCY WITHOUT HARM TO MOTHER OR CHILD. JAMA. 1955;159(11):1112–1113. doi:10.1001/jama.1955.02960280034008
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