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January 15, 1949

Total Protein, Globulin and Albumin in Lumbar Fluid in Cryptogenic Epilepsy: A Clinical Methodological Study

JAMA. 1949;139(3):188. doi:10.1001/jama.1949.02900200058030

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The author has measured the total protein and the globulinalbumin quotients in 133 patients with epilepsy (21 of these "symptomatic") and in 67 "control" patients. The data are presented in detail in fifteen tables and four charts, and discussed intelligently against a background of more than 200 references. The method of Izikowitz was employed. In 5.5 per cent of 110 patients with cryptogenic epilepsy, the total protein was above the normal limit. The globulin-albumin quotient was below normal in 10 per cent. This abnormal ratio was due both to unusually low values for globulin and high values for albumin. Measurements on successive occasions might produce different values. Thus, a subnormal quotient was found at least once in 17 per cent of 110 patients. However, abnormalities could not be related to the time interval after a seizure, to the frequency of attacks, to the duration of the epilepsy or to electroencephalographic

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