In November, 1954, Dr. Alexander Brunschwig1 described the trial of a method for cytological detection of carcinoma of the uterine cervix by the use of a specially designed vaginal tampon. The concept of such a mass screening for early cancer detection originated with Dr. Andre Draghi, who designed a special vaginal tampon to implement that technique. This tampon consists of a tightly compressed cylinder of cotton partially encased in a sheath of nylon (see figure). A group of 227 patients were studied by this screening method by Dr. Brunschwig. He concluded from this study that the method appeared to be feasible but felt that the evaluation of the method must await an actual large-scale trial.
The cytological evaluation of the smears made from the 227 patients studied by Dr. Brunschwig was done by Dr. George N. Papanicolaou.2 Dr. Papanicolaou felt that the analyzed results of the tampon smears
Thornton MJ. TAMPON METHOD FOR MASS SCREENING TO DETECT CARCINOMA OF CERVIX UTERI. JAMA. 1955;159(12):1177–1180. doi:10.1001/jama.1955.02960290003002
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