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November 19, 1955

Statistics of Therapeutic Trials

JAMA. 1955;159(12):1251-1252. doi:10.1001/jama.1955.02960290077021

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This book is designed to serve as a guide for physicians who wish to apply statistical techniques in the evaluation of therapeutic data. Rather than serving as a condensed textbook on the statistics of probability applied to a subclass of medical statistics, it provides the practitioner with a reading knowledge of some simple approaches to the process of statistical inference. "Therapeutic statistics" is a summary term for the statistical procedures that are used in the design and evaluation of results of therapeutic trials carried out to compare different treatments. Thus, this term comprises both the statistical principles of the single trial, referred to as clinical statistics, and comparative therapeutics, which embodies the comparison of the results obtained at different times and places and in different classes of patients under varying conditions. In the effort to provide a quantitative measure for comparing the utility of alternative procedures, the magnitude of differences

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