Observations in brucellosis in human beings have indicated that the simultaneous administration of streptomycin and sulfadiazine is more effective therapeutically than when either drug is given alone.1 Experimental studies with infected fertilized hens' eggs have also supported this conclusion.2 Furthermore, it has been shown experimentally that the combination of streptomycin and sulfadiazine acts synergistically against the three species of Brucella.3 In the initial communication from our clinic on the treatment of human beings with the combination, 9 patients were included in the study.1c The results were more satisfactory than had been obtained with any other form of therapy up to that time at the University of Minnesota Hospitals. A subsequent report embraced a total of 17 patients treated with streptomycin and a sulfonamide drug.4
Continued experience with this combined therapy in brucellosis in human beings has provided further evidence that it constitutes a satisfactory form
SPINK WW, HALL WH, SHAFFER J, BRAUDE AI. TREATMENT OF BRUCELLOSIS WITH STREPTOMYCIN AND A SULFONAMIDE DRUG. JAMA. 1949;139(6):352–356. doi:10.1001/jama.1949.02900230006002
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: