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December 3, 1955


JAMA. 1955;159(14):1353-1357. doi:10.1001/jama.1955.02960310017009

Because of its ability to demonstrate the bile ducts when the gallbladder has been resected or has ceased to function, sodium iodipamide (Cholografin) offered immediate promise in the examination of patients with digestive complaints persisting after cholecystectomy. In recent months we have examined 121 individuals with the varied symptoms of the postcholecystectomy syndrome, and we present in this paper our analysis of their intravenous cholangiograms. We offer, in addition, our observations in a control series of 46 patients who reported themselves free of symptoms after cholecystectomy.

The postcholecystectomy syndrome is a familiar and discouraging disorder characterized by abdominal pain, nausea, and intolerance to certain foods, continuing unabated after cholecystectomy. Its very name is ambiguous in its implication that the operation has caused symptoms, when, in fact, it has simply failed to relieve them; for this reason we prefer Best's1 more accurate term, "the recurrent biliary tract syndrome." Causes for

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