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December 3, 1955


JAMA. 1955;159(14):1358-1361. doi:10.1001/jama.1955.02960310022010

Since the introduction of iopanoic acid (Telepaque) in 1951, extensive clinical application has demonstrated that this medium represents an ideal cholecystographic agent.1 Iopanoic acid [β-(3-amino-2, 4, 6-triiodophenyl)-α-ethylpropionic acid] contains 66.68% iodine. This triiodide is readily absorbed by the small intestine and is excreted in the bile within two hours after oral administration. Maximum concentration in the gallbladder occurs at from 10 to 12 hours. Iopanoic acid is excreted mainly through the intestinal tract; elimination is rapid and complete within 48 hours. Toxic reactions to the medium are rare, and side-effects are minimal. In addition to providing visualization of the gallbladder, in a significant percentage of examinations the bile ducts, particularly the cystic and common ducts, are outlined.2

The accuracy of cholecystography in detecting the presence of gallbladder disease and cholelithiasis has been estimated at 99%.3 This high degree of diagnostic reliability has made cholecystography one of the