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Article
January 7, 1956

USE OF MALARIA THERAPY IN THE NEPHROTIC SYNDROME

Author Affiliations

Minneapolis

Trainee, National Institute of Arthritis and Metabolic Diseases (Dr. Gilbertsen) and Instructor in Medicine (Dr. Bashour), Department of Medicine, University of Minnesota Hospitals.

JAMA. 1956;160(1):25-30. doi:10.1001/jama.1956.02960360027006
Abstract

• Six patients in the nephrotic phase of chronic glomerulonephritis were inoculated with Plasmodium vivax. After incubation periods of from one to nine days, clinical malaria developed in five of the patients. It was terminated, after the desired number of episodes of fever, by means of cholroquine.

In two cases the inoculation was followed by a massive diuresis, a loss of all edema, and the disappearance of albuminuria and hypoproteinemia; a lasting remission, by clinical and chemical criteria, was obtained. In some instances, hypertension of long standing was relieved. One patient did not respond favorably, and in one other three inoculations failed to induce malaria.

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