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March 12, 1949


JAMA. 1949;139(11):719-720. doi:10.1001/jama.1949.02900280035012

Doubt of the validity of the concept that the gastrointestinal tract is the usual portal of entry for poliomyelitis virus is expressed by Faber1 and his associates of the Department of Pediatrics, Stanford University, as a result of inoculation experiments on cynomolgus monkeys. In their first series of tests poliomyelitis virus (Per strain) was enclosed in crisco®-coated gelatin capsules and introduced by means of a curved metal cannula into the stomachs of 26 unanesthetized monkeys. None of these animals contracted poliomyelitis. Sabin and Ward2 had previously found that the same virus administered by simple feeding, which involves simultaneous exposure of both the pharyngeal and gastrointestinal surfaces, induced infection in 40 per cent of their monkeys. Faber's negative results therefore suggest that as compared to the oropharyngeal surfaces the gastrointestinal mucosa is relatively impervious to the virus.

In a second series of tests, 18 cynomolgus monkeys were fed with

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