The purpose of this investigation is a critical evaluation of aerosol alternating negative pressure therapy given once daily in cases of chronic purulent sinusitis.
The inhalation route for administration of various medicaments, such as bronchodilator and bronchovasoconstrictor drugs, and in more recent years chemotherapeutic and antibiotic groups of drugs, is now well established in the treatment of certain types of bronchopulmonary disease.1 Inhalational therapy of diseases of the upper part of the respiratory tract has also been extended to include antibotic aerosols. Some favorable clinical results were reported by Vermilye1j in cases of acute sinusitis and acute pharyngitis and in acute exacerbations of chronic sinusitis. However, it was first demonstrated by Barach and his co-workers2 that alternating application of negative pressure with inhalation of penicillin aerosol was necessary to insure the introduction of penicillin into the maxillary sinuses and thereby prove efficacious in therapy of chronic sinusitis.
EDUARDO R. PONS, WALTER M. GLASS, BETTINA GARTHWAITE. EVALUATION OF AEROSOL-NEGATIVE PRESSURE THERAPYGiven Once Daily in Chronic Purulent Sinusitis. JAMA. 1949;139(12):766–772. doi:10.1001/jama.1949.02900290012004