• Meperidine was administered intravenously by continuous drip in a series of surgical patients as an adjunct to anesthesia with thiopental sodium, nitrous oxide, and oxygen. The results were compared with those from a group anesthetized with thiopental sodium, nitrous oxide, and oxygen but without the meperidine.
The meperidine was found to reduce by 51% the amount of thiopental sodium required per hour. The continuous drip method is reported to give a smoother anesthesia, with less danger of severe respiratory depression and hypotension, than is obtained by single injections of meperidine.
Ausherman HM, Nowill WK, Stephen CR. CONTROLLED ANALGESIA WITH CONTINUOUS DRIP MEPERIDINEANALYSIS OF ONE THOUSAND CASES. JAMA. 1956;160(3):175–179. doi:10.1001/jama.1956.02960380023007
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