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Article
January 21, 1956

CONTROLLED ANALGESIA WITH CONTINUOUS DRIP MEPERIDINEANALYSIS OF ONE THOUSAND CASES

JAMA. 1956;160(3):175-179. doi:10.1001/jama.1956.02960380023007
Abstract

• Meperidine was administered intravenously by continuous drip in a series of surgical patients as an adjunct to anesthesia with thiopental sodium, nitrous oxide, and oxygen. The results were compared with those from a group anesthetized with thiopental sodium, nitrous oxide, and oxygen but without the meperidine.

The meperidine was found to reduce by 51% the amount of thiopental sodium required per hour. The continuous drip method is reported to give a smoother anesthesia, with less danger of severe respiratory depression and hypotension, than is obtained by single injections of meperidine.

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